The order of the platforms is raid comp dependent and with 25 people in the raid, raid cooldowns are easier to come by. We went Ysera, Nozdormu, Alexstrasza and then Kalecgos on 25 man vs. Ysera, Alexstrasza, Nozdormu, and Kalecgos on 10 man. We went with two disc priests so we could PW:B on platforms 3 and 4. The dps requirements seem tougher on 25 man, which is why we swapped the order so we only had to worry about Blistering Tentacles on platform 4.
Since this fight is longer than 10 minutes we are using hero on the first platform as soon as the Mutated Corruption had spawned. While not strictly needed, there was no reason not to do this.
DPS on the first two platforms is pretty easy since you have all of the DPs buffs intact. So we sent one DPS over to Kalecgos' platform to whittle down the tentacle ahead of time. This is safe to do until Cataclysm starts up, so the DPS had just under 2 minutes each time to work on the (wing) tentacle before returning to the raid. He was able to knock off about 10% of the Tentacle's health doing this. He stayed with the raid on platforms 3 and 4. This gave us a buffer of about 8 extra seconds on Kalecgos' platform, which was a significant help in getting us through that before Cataclysm finished. In 10 man, I am guessing that you could send one person over to Kalecgos's platform while working on Ysera's platform (the first one). With heroism and all the buffs, missing one person there should not be an issue. Since the relative dps of a single player on 10 man is more than double that of a player on 25 man, that should be enough to get the 10% start on Kalecgos.
On phase two, I had the tanks do the following to pick up the Elementium Terrors (the large adds). We had the healers stack on the prot warrior who did an AOE grab on the adds (he was standing in Nozdormu's zone). I gave the offtank, a feral druid, this macro to use:
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/tar Elementium Terror /cast Growl(Bear Form) /cast Faerie Fire (Feral)(Feral) /script SetRaidTarget("target",8);
The final piece of the puzzle for us was proper control of dps/healing in Phase 2. There is a tendency to think of Phase 2 as strictly a burn phase, but a key element is healing, especially when Deathwing drops to 10% and then 5% health and his AOE damage increases significantly. What we did to manage this phase was to stop dps at about 12% (with DoTs still ticking) before the second set of adds spawned. Then we hit heroism as soon as we finished the second add phase and burned him from 11/12% down ignoring the third set of adds who had just spawned when he died. On previous attempts we had used hero earlier and gotten Deathwing to about 7% before the second set of adds spawned and simply could not keep the raid alive through a kill. At some point our dps will be high enough to kill him before the second set of adds start impacting the raid, but we are not there yet, but we do have enough raid dps that we had to call a hard stop 5-10 seconds before the second set of adds had spawned. Another benefit of this approach was having heroism active through to the end of the fight for the healers. I believe we had 24 people standing at the end, with only two deaths during the course of the kill.